设为首页 | 加入收藏
| 欢迎光临本站!

消化内镜学分会官方网站

当前位置:文献追踪 > 国内外期刊

治疗食管狭窄新型覆膜金属支架防移位性能:在动物体内的研究

发布日期:2014-1-29 12:40:14 文章来源:GIE(July,2011) 作者次数:1129

    治疗食管狭窄新型覆膜金属支架防移位性能:在动物体内的研究

    背景
    覆膜式自膨式金属支架(SEMSs)与未覆膜式相比,它的移位发生率更高。
    目的
    设计方案
    新型支架(长80mm,直径20-24mm)上有多个突起,设计这些突起是为了将其从内部的有机硅膜中分离出来,从而便于在支架展开后突起能嵌入到黏膜里。此研究中22只beagle犬因食管中部狭窄而受到环周內镜下黏膜切除术(EMR)治疗。2周后,往对照组(11只)中植入常规覆膜支架,实验组(11只)中植入新型覆膜自膨式金属支架。
     
    环境
    动物实验室
    干预
    先采用环周內镜下黏膜切除术(EMR)治疗食管中部狭窄,然后进行內镜下常规支架或新型支架放置。
    主要评价指标
    移位,并发症,生存情况食管组织病理
    结果
    对照组与实验组中犬食管狭窄直径没有显著差异,分别10mm,11mm(P=0.52)。术后3天内,对照组中所有支架发生移位,而实验组中有6个发生移位(100%对55%,P=0.035)。未出现与支架植入直接相关的严重并发症。
    局限性
    由于3天内对照组中所有常规支架都发生移位,故没法比较二者之间出现的并发症,生存率,食管组织病理学情况。
    结论
    新型覆膜自膨式金属支架SEMS)的防迁移能力比常规覆膜金属支架(SEMS)强。
     
    缩写: SEMS为自膨式金属支架。
     
    --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
     

    Antimigration property of a newly designed covered metal stent for esophageal stricture: an in vivo animal study

    Background
    Covered self-expandable metal stents (SEMSs) are associated with a higher migration rate than uncovered SEMSs.
     
    Objective
    The antimigration property of a novel covered SEMS was investigated in a canine esophageal stricture model.
     
    Design
    The new stent (80 mm in length, 20 or 24 mm in diameter) has multiple protuberances on its body that were designed to be separated from the inner silicone membrane so that they could be embedded into the mucosa after deployment. Twenty-two beagle dogs were subjected to circumferential EMR in the middle esophagus for stricture formation. After 2 weeks, conventional covered stents were inserted in a control group (n = 11), and the newly designed covered SEMSs were inserted in a study group (n = 11).
     
    Setting
    Animal laboratory
     
    Interventions
    Circumferential EMR of the middle esophagus for stricture formation, followed by endoscopic placement of a conventional or newly designed stent.
    Main Outcome Measurements
    Migration, complications, survival, and esophageal histopathology.
     
    Results
    There was no significant difference in the diameter of the esophageal stricture between the control and study groups (10 mm vs 11 mm, P = .52). Within 3 days, all stents in the control group had migrated, whereas 6 had migrated in the study group (100% vs 55%, P = .035). There were no significant complications directly associated with stent insertion.
     
    Limitations
    Complications, survival, and esophageal histopathology could not be compared because all of the conventional stents migrated in the control group within 3 days.
    Conclusions
    The newly designed covered SEMS is more resistant to migration than the conventional covered SEMS.
    Abbreviation: SEMS, self-expandable metal stent
     
     
    (作者:)
相关评论
用户名: 登录